Dr. Vinay Kumar Singh

DOI: https://doi.org/10.5281/zenodo.23391823

Music is an important part of human life. It can affect our emotions, memory, thinking, stress, and behaviour. Scientists are also interested in understanding whether these effects can influence biological processes inside the body. Music does not normally change the actual DNA sequence. However, it may influence how some genes work or how strongly they are expressed. This area can be studied using molecular biology and bioinformatics. Bioinformatics helps scientists analyse large amounts of biological information such as DNA, RNA, and gene-expression data. Forensic psychology helps us understand how people respond to music emotionally and mentally. Musicology helps us understand the characteristics of music, such as rhythm, melody, harmony, tempo, and structure. By combining these three areas, researchers can study how different types of music may influence psychological, physiological, and molecular responses.

Music; DNA; gene expression; epigenetics; bioinformatics; forensic psychology; forensic musicology; stress; neuroscience; transcriptomics; DNA methylation; music perception.

Music can influence human emotions, memory, stress, and physiological responses. These effects provide a possible pathway through which music may indirectly influence biological processes involved in gene regulation. However, music does not normally change the actual DNA sequence. The more accurate concept is that music may influence gene expression and possibly epigenetic regulation through psychological, neural, hormonal, and cellular pathways. Forensic psychology helps explain individual differences in emotional response, memory, perception, and behavior. Musicology helps describe and analyze the musical stimulus. Bioinformatics provides the computational methods required to analyze large amounts of molecular data. Therefore, the relationship can be summarized as: Music → Psychology → Physiology → Gene Regulation → Bioinformatics. This interdisciplinary approach provides an interesting and potentially valuable area for postgraduate research. However, more experimental evidence is required before specific gene-expression or epigenetic changes caused by music can be considered established or useful as forensic biomarkers.

1.Adiasto, K., Beckers, D. G. J., van Hooff, M. L. M., Roelofs, K., & Geurts, S. A. E. (2022). Music listening and stress recovery in healthy individuals: A systematic review with meta-analysis of experimental studies. PloS one, 17(6), e0270031. https://doi.org/10.1371/journal.pone.0270031 2.Adolphs R. (2013). The biology of fear. Current biology : CB, 23(2), R79–R93. https://doi.org/10.1016/j.cub.2012.11.055 3.Arnold, C. A., Bagg, M. K., & Harvey, A. R. (2024). The psychophysiology of music-based interventions and the experience of pain. Frontiers in psychology, 15, 1361857. https://doi.org/10.3389/fpsyg.2024.1361857 4.Barbaresi, M., Nardo, D., & Fagioli, S. (2024). Physiological Entrainment: A Key Mind-Body Mechanism for Cognitive, Motor and Affective Functioning, and Well-Being. Brain sciences, 15(1), 3. https://doi.org/10.3390/brainsci15010003 5.Barnett, K. S., & Vasiu, F. (2024). How the arts heal: a review of the neural mechanisms behind the therapeutic effects of creative arts on mental and physical health. Frontiers in behavioral neuroscience, 18, 1422361. https://doi.org/10.3389/fnbeh.2024.1422361 6.Bartel, L., & Mosabbir, A. (2021). Possible Mechanisms for the Effects of Sound Vibration on Human Health. Healthcare (Basel, Switzerland), 9(5), 597. https://doi.org/10.3390/healthcare9050597 7.Blasco-Magraner, J. S., Bernabé-Valero, G., Marín-Liébana, P., & Botella-Nicolás, A. M. (2023). Changing positive and negative affects through music experiences: a study with university students. BMC psychology, 11(1), 76. https://doi.org/10.1186/s40359-023-01110-9 8.Chen L. (2023). Influence of music on the hearing and mental health of adolescents and countermeasures. Frontiers in neuroscience, 17, 1236638. https://doi.org/10.3389/fnins.2023.1236638 9.Córdova, A., Caballero-García, A., Drobnic, F., Roche, E., & Noriega, D. C. (2023). Influence of Stress and Emotions in the Learning Process: The Example of COVID-19 on University Students: A Narrative Review. Healthcare (Basel, Switzerland), 11(12), 1787. https://doi.org/10.3390/healthcare11121787 10.De Francesco, L., Schintu, S., Mazza, A., Ricci, R., & Dal Monte, O. (2025). What you listen to makes a difference: The impact of music on attention and well-being. Annals of the New York Academy of Sciences, 1552(1), 273–283. https://doi.org/10.1111/nyas.70049 11.Gómez-Carballa, A., Navarro, L., Mallah, N. E. Z., Bello, X., Pischedda, S., Viz-Lasheras, S., Currás, M. J., Ferreirós-Vidal, I., Mallah, N., Montoto-Louzao, J., Camino-Mera, A., Castelo-Martínez, L., Rey-Vázquez, S., Redondo, L., Dacosta-Urbieta, A., Rivero-Calle, I., Rodríguez-Tenreiro, C., Martinón-Torres, F., & Salas, A. (2025). Music elicits different gene expression responses in the buccal cavity of age-related cognitive disorders patients and healthy controls. Frontiers in aging neuroscience, 17, 1622816. https://doi.org/10.3389/fnagi.2025.1622816 12.Gómez-Carballa, A., Navarro, L., Pardo-Seco, J., Bello, X., Pischedda, S., Viz-Lasheras, S., Camino-Mera, A., Currás, M. J., Ferreirós, I., Mallah, N., Rey-Vázquez, S., Redondo, L., Dacosta-Urbieta, A., Caamaño-Viña, F., Rivero-Calle, I., Rodriguez-Tenreiro, C., Martinón-Torres, F., & Salas, A. (2023). Music compensates for altered gene expression in age-related cognitive disorders. Scientific reports, 13(1), 21259. https://doi.org/10.1038/s41598-023-48094-5 13.Johnson J. (2024). Effect of emotions on learning, memory, and disorders associated with the changes in expression levels: A narrative review. Brain circulation, 10(2), 134–144. https://doi.org/10.4103/bc.bc_86_23 14.Kaisler, R. E., Fede, M., Diltsch, U., Probst, T., & Schaffler, Y. (2023). Common mental disorders in Gestalt therapy treatment: a multiple case study comparing patients with moderate and low integrated personality structures. Frontiers in psychology, 14, 1304726. https://doi.org/10.3389/fpsyg.2023.1304726 15.Kanduri, C., Raijas, P., Ahvenainen, M., Philips, A. K., Ukkola-Vuoti, L., Lähdesmäki, H., & Järvelä, I. (2015). The effect of listening to music on human transcriptome. PeerJ, 3, e830. https://doi.org/10.7717/peerj.830 16.Kearney, B. E., & Lanius, R. A. (2022). The brain-body disconnect: A somatic sensory basis for trauma-related disorders. Frontiers in neuroscience, 16, 1015749. https://doi.org/10.3389/fnins.2022.1015749 17.Kučikienė, D., & Praninskienė, R. (2018). The impact of music on the bioelectrical oscillations of the brain. Acta medica Lituanica, 25(2), 101–106. https://doi.org/10.6001/actamedica.v25i2.3763 18.Landis-Shack, N., Heinz, A. J., & Bonn-Miller, M. O. (2017). Music Therapy for Posttraumatic Stress in Adults: A Theoretical Review. Psychomusicology, 27(4), 334–342. https://doi.org/10.1037/pmu0000192 19.Masuo, Y., Satou, T., Takemoto, H., & Koike, K. (2021). Smell and Stress Response in the Brain: Review of the Connection between Chemistry and Neuropharmacology. Molecules (Basel, Switzerland), 26(9), 2571. https://doi.org/10.3390/molecules26092571 20.Miendlarzewska, E. A., & Trost, W. J. (2014). How musical training affects cognitive development: rhythm, reward and other modulating variables. Frontiers in neuroscience, 7, 279. https://doi.org/10.3389/fnins.2013.00279 21.Movahed Abtahi, M., & Kerns, K. A. (2017). Attachment and emotion regulation in middle childhood: changes in affect and vagal tone during a social stress task. Attachment & human development, 19(3), 221–242. https://doi.org/10.1080/14616734.2017.1291696 22.Movalled, K., Sani, A., Nikniaz, L., & Ghojazadeh, M. (2023). The impact of sound stimulations during pregnancy on fetal learning: a systematic review. BMC pediatrics, 23(1), 183. https://doi.org/10.1186/s12887-023-03990-7 23.Muehsam, D., & Ventura, C. (2014). Life rhythm as a symphony of oscillatory patterns: electromagnetic energy and sound vibration modulates gene expression for biological signaling and healing. Global advances in health and medicine, 3(2), 40–55. https://doi.org/10.7453/gahmj.2014.008 24.Nair, P. S., Kuusi, T., Ahvenainen, M., Philips, A. K., & Järvelä, I. (2019). Music-performance regulates microRNAs in professional musicians. PeerJ, 7, e6660. https://doi.org/10.7717/peerj.6660 25.Noda, Y., & Noda, T. (2025). The Influence of Music on Mental Health Through Neuroplasticity: Mechanisms, Clinical Implications, and Contextual Perspectives. Brain sciences, 15(11), 1248. https://doi.org/10.3390/brainsci15111248 26.Olff, M., Hein, I., Amstadter, A. B., Armour, C., Skogbrott Birkeland, M., Bui, E., Cloitre, M., Ehlers, A., Ford, J. D., Greene, T., Hansen, M., Harnett, N. G., Kaminer, D., Lewis, C., Minelli, A., Niles, B., Nugent, N. R., Roberts, N., Price, M., Reffi, A. N., … Vujanovic, A. A. (2025). The impact of trauma and how to intervene: a narrative review of psychotraumatology over the past 15 years. European journal of psychotraumatology, 16(1), 2458406. https://doi.org/10.1080/20008066.2025.2458406 27.Paller, K. A., Creery, J. D., & Schechtman, E. (2021). Memory and Sleep: How Sleep Cognition Can Change the Waking Mind for the Better. Annual review of psychology, 72, 123–150. https://doi.org/10.1146/annurev-psych-010419-050815 28.Pauwels, E. K., Volterrani, D., Mariani, G., & Kostkiewics, M. (2014). Mozart, music and medicine. Medical principles and practice : international journal of the Kuwait University, Health Science Centre, 23(5), 403–412. https://doi.org/10.1159/000364873 29.Peters, V., Bissonnette, J., Nadeau, D., Gauthier-Légaré, A., & Noël, M. A. (2024). The impact of musicking on emotion regulation: A systematic review and meta-analysis. Psychology of music, 52(5), 548–568. https://doi.org/10.1177/03057356231212362 30.Piccardi, L., Palmiero, M., & Nori, R. (2024). The Role of Sounds and Music in Emotion and Cognition. Brain sciences, 14(3), 192. https://doi.org/10.3390/brainsci14030192 31.Poćwierz-Marciniak, I., & Harciarek, M. (2021). The Effect of Musical Stimulation and Mother’s Voice on the Early Development of Musical Abilities: A Neuropsychological Perspective. International journal of environmental research and public health, 18(16), 8467. https://doi.org/10.3390/ijerph18168467 32.Rehfeldt, R. A., Tyndall, I., & Belisle, J. (2021). Music as a Cultural Inheritance System: A Contextual-Behavioral Model of Symbolism, Meaning, and the Value of Music. Behavior and social issues, 30(1), 749–773. https://doi.org/10.1007/s42822-021-00084-w 33.Reybrouck, M., Podlipniak, P., & Welch, D. (2019). Music and Noise: Same or Different? What Our Body Tells Us. Frontiers in psychology, 10, 1153. https://doi.org/10.3389/fpsyg.2019.01153 34.Rossi, C., Oasi, O., & Colombo, B. (2024). Personality characteristics, music-listening, and well-being: a systematic and scoping review. Research in psychotherapy (Milano), 27(1), 742. https://doi.org/10.4081/ripppo.2024.742 35.Sachs, M. E., Damasio, A., & Habibi, A. (2015). The pleasures of sad music: a systematic review. Frontiers in human neuroscience, 9, 404. https://doi.org/10.3389/fnhum.2015.00404 36.Schoeller, F., Jain, A., Pizzagalli, D. A., & Reggente, N. (2024). The neurobiology of aesthetic chills: How bodily sensations shape emotional experiences. Cognitive, affective & behavioral neuroscience, 24(4), 617–630. https://doi.org/10.3758/s13415-024-01168-x 37.T Zaatar, M., Alhakim, K., Enayeh, M., & Tamer, R. (2023). The transformative power of music: Insights into neuroplasticity, health, and disease. Brain, behavior, & immunity – health, 35, 100716. https://doi.org/10.1016/j.bbih.2023.100716 38.Taruffi, L., Pehrs, C., Skouras, S., & Koelsch, S. (2017). Effects of Sad and Happy Music on Mind-Wandering and the Default Mode Network. Scientific reports, 7(1), 14396. https://doi.org/10.1038/s41598-017-14849-0 39.Thoma, M. V., La Marca, R., Brönnimann, R., Finkel, L., Ehlert, U., & Nater, U. M. (2013). The effect of music on the human stress response. PloS one, 8(8), e70156. https://doi.org/10.1371/journal.pone.0070156 40.Toader, C., Tataru, C. P., Florian, I. A., Covache-Busuioc, R. A., Bratu, B. G., Glavan, L. A., Bordeianu, A., Dumitrascu, D. I., & Ciurea, A. V. (2023). Cognitive Crescendo: How Music Shapes the Brain’s Structure and Function. Brain sciences, 13(10), 1390. https://doi.org/10.3390/brainsci13101390 41.Trasmundi, S. B., & Toro, J. (2023). Mind wandering in reading: An embodied approach. Frontiers in human neuroscience, 17, 1061437. https://doi.org/10.3389/fnhum.2023.1061437 42.Valenti, D., & Atlante, A. (2024). Sound Matrix Shaping of Living Matter: From Macrosystems to Cell Microenvironment, Where Mitochondria Act as Energy Portals in Detecting and Processing Sound Vibrations. International journal of molecular sciences, 25(13), 6841. https://doi.org/10.3390/ijms25136841 43.Wang, T., Zhao, Y., & Yin, M. (2022). Analysis and research on the influence of music on students’ mental health under the background of deep learning. Frontiers in psychology, 13, 998451. https://doi.org/10.3389/fpsyg.2022.998451 44.Woods, B., Rai, H. K., Elliott, E., Aguirre, E., Orrell, M., & Spector, A. (2023). Cognitive stimulation to improve cognitive functioning in people with dementia. The Cochrane database of systematic reviews, 1(1), CD005562. https://doi.org/10.1002/14651858.CD005562.pub3

Dr. Vinay Kumar Singh (2026). Effect of Music on Gene Expression and Epigenetic Regulation: An Integrated Study Using Bioinformatics, Forensic Psychology and Musicology. International Journal of Research in Engineering Technology, 11(5), 72–85. ISSN: 2455-1341. DOI: https://doi.org/10.5281/zenodo.23391823